Impaired coronary flow reserve: a pre-requisite for coronary revascularization

Fractional flow reserve to guide coronary revascularization.

Fractional flow reserve (FFR) has become an increasingly important index for decision making with respect to revascularization of coronary artery stenosis. It is the gold standard to indicate whether a particular stenosis is responsible for inducible ischemia and it is generally accepted that a stenosis with an ischemic value of FFR is responsible for angina pectoris and a worse outcome, and sh...

Ischemia-based Coronary Revascularization: Beyond Anatomy and Fractional Flow Reserve

Treatment strategies for patients with coronary artery disease (CAD) should be based on objective evidence of inducible ischemia in the subtended myocardium to improve clinical outcomes, symptoms, and cost-effectiveness. Fractional flow reserve (FFR) is the most verified index to-date for invasively evaluating lesion-specific myocardial ischemia. Favorable results from large clinical trials tha...

Coronary flow reserve.

A case of multiple coronary artery aneurysms: Successful revascularization

Introduction: Multiple coronary artery aneurysm is a rare anomaly which could be congenital or acquired. Its complications including sudden cardiac death, clot and distal emboli, rupture and bleeding or fistula. Decision about its management depends on aneurysm conditions and the Patient's clinical situation Case Report: A 55 years old patient with unstable angina and multiple coronary ar...

AT1 receptors: coronary flow and flow reserve.

Angiotensin II, through its effects at the angiotensin-type 1 receptor, elevates arterial pressure and exacerbates hypertensive heart disease. Alterations in coronary hemodynamics, including reductions in coronary blood flow and flow reserve promotes coronary insufficiency and contributes to the increased cardiovascular risk associated with these conditions. In spontaneously hypertensive rats, ...